Toshifumi Yokota Selected Research

Inborn Genetic Diseases (Disease, Hereditary)

1/2022	Antisense and Gene Therapy Options for Duchenne Muscular Dystrophy Arising from Mutations in the N-Terminal Hotspot.
1/2020	Detection of Locked Nucleic Acid Gapmers from Mouse Muscle Samples Using ELISA.
1/2020	Development and Clinical Applications of Antisense Oligonucleotide Gapmers.
1/2019	Restoring Dystrophin Expression in Duchenne Muscular Dystrophy: Current Status of Therapeutic Approaches.
11/2018	Evaluation of Exon Inclusion Induced by Splice Switching Antisense Oligonucleotides in SMA Patient Fibroblasts.
1/2018	Tips to Design Effective Splice-Switching Antisense Oligonucleotides for Exon Skipping and Exon Inclusion.
1/2018	Designing Effective Antisense Oligonucleotides for Exon Skipping.
1/2018	Direct Reprogramming of Human DMD Fibroblasts into Myotubes for In Vitro Evaluation of Antisense-Mediated Exon Skipping and Exons 45-55 Skipping Accompanied by Rescue of Dystrophin Expression.
11/2017	Quantitative Antisense Screening and Optimization for Exon 51 Skipping in Duchenne Muscular Dystrophy.
10/2017	Immortalized Muscle Cell Model to Test the Exon Skipping Efficacy for Duchenne Muscular Dystrophy.

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Toshifumi Yokota Research Topics

Disease

68	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 02/2022 - 05/2002
17	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 09/2012
15	Muscular Dystrophies (Muscular Dystrophy) 01/2022 - 08/2010
11	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 07/2021 - 08/2013
6	Cardiomyopathies (Cardiomyopathy) 02/2022 - 04/2017
4	Dysferlinopathy 10/2019 - 08/2013
4	Muscular Diseases (Myopathy) 12/2018 - 07/2006
4	Walker-Warburg Syndrome 01/2018 - 10/2011
3	Neuromuscular Diseases (Neuromuscular Disease) 09/2020 - 06/2014
3	Huntington Disease (Huntington's Disease) 01/2020 - 08/2013
3	Facioscapulohumeral Muscular Dystrophy 01/2020 - 02/2014
3	Myotonic Dystrophy (Dystrophia Myotonica) 01/2020 - 08/2013
3	type 2C Limb-girdle muscular dystrophy 10/2019 - 01/2018
3	type 2B Limb-girdle muscular dystrophy 01/2018 - 08/2013
3	Miyoshi myopathy 01/2018 - 08/2013
2	Heterotopic Ossification (Ectopic Ossification) 01/2022 - 01/2018
2	Muscle Weakness 07/2021 - 01/2019
2	Transthyretin-Related Hereditary Amyloidosis 01/2020 - 01/2020
2	Costello Syndrome 01/2020 - 01/2020
2	Hyperlipoproteinemia Type I (Lipoprotein Lipase Deficiency, Familial) 01/2020 - 01/2020
2	Neoplasms (Cancer) 01/2020 - 01/2020
2	Sarcoglycanopathies 01/2018 - 01/2018
2	Distal Myopathy with Anterior Tibial Onset 01/2018 - 08/2013
2	Myositis Ossificans (Fibrodysplasia Ossificans Progressiva) 01/2018 - 01/2018
1	Respiratory Insufficiency (Respiratory Failure) 01/2021
1	Wasting Syndrome (Wasting Disease) 01/2021
1	Musculoskeletal Diseases (Musculoskeletal Disease) 09/2020
1	Polyneuropathies (Polyneuropathy) 01/2020
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2020
1	Lipodystrophy 01/2020
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 01/2020
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020
1	Fibrosis (Cirrhosis) 01/2020
1	Dyslipidemias (Dyslipidemia) 01/2020
1	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 01/2020
1	Homozygous Familial Hypercholesterolemia 01/2020
1	Epidermolysis Bullosa Dystrophica (Dystrophic Epidermolysis Bullosa) 01/2018
1	merosin negative Muscular dystrophy congenital 01/2018
1	Rupture 01/2018
1	Usher Syndromes (Usher Syndrome) 01/2018
1	Schaaf-Yang syndrome 01/2016
1	Communicable Diseases (Infectious Diseases) 06/2014
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 08/2013
1	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 08/2013
1	Heart Failure 01/2013
1	Hypercholesterolemia 10/2011
1	Hypertrophy 09/2002

Drug/Important Bio-Agent (IBA)

46	DystrophinIBA 02/2022 - 05/2002
23	Antisense OligonucleotidesIBA 01/2021 - 01/2005
16	Proteins (Proteins, Gene)FDA Link 02/2022 - 06/2009
11	MorpholinosIBA 03/2019 - 08/2010
9	Messenger RNA (mRNA)IBA 12/2018 - 06/2007
7	eteplirsenIBA 01/2020 - 01/2017
5	nusinersenIBA 01/2020 - 01/2018
4	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 06/2014
4	Pharmaceutical PreparationsIBA 01/2020 - 04/2017
4	DysferlinIBA 12/2018 - 01/2018
3	OligonucleotidesIBA 03/2018 - 06/2007
2	Peptides (Polypeptides)IBA 01/2022 - 01/2017
2	activin AIBA 01/2022 - 01/2018
2	Cell-Penetrating PeptidesIBA 02/2021 - 01/2017
2	Nonsense Codon (Nonsense Mutation)IBA 01/2021 - 09/2012
2	mipomersenIBA 01/2020 - 01/2020
2	ISIS 304801IBA 01/2020 - 01/2020
2	InotersenIBA 01/2020 - 01/2020
2	LipidsIBA 01/2020 - 10/2011
2	Triglycerides (Triacylglycerol)IBA 01/2020 - 01/2020
2	Laminin (Merosin)IBA 01/2018 - 01/2018
1	Telomerase (Telomerase Reverse Transcriptase)IBA 01/2021
1	CyclinsIBA 01/2021
1	viltolarsenIBA 01/2021
1	Amyloid (Amyloid Fibrils)IBA 01/2020
1	Prealbumin (Transthyretin)IBA 01/2020
1	RNA (Ribonucleic Acid)IBA 01/2020
1	NucleotidesIBA 11/2018
1	Nucleic AcidsIBA 11/2018
1	Fluorescent Dyes (Fluorescent Probes)IBA 01/2018
1	casimersenIBA 01/2018
1	golodirsenIBA 01/2018
1	RNA Precursors (Precursor, mRNA)IBA 01/2018
1	Arginine (L-Arginine)FDA Link 01/2017
1	homeobox protein PITX1IBA 02/2014
1	Retroelements (Retrotransposon)IBA 10/2011
1	Codon (Codons)IBA 07/2011

Therapy/Procedure

28	Therapeutics 02/2022 - 05/2002
2	Precision Medicine 09/2020 - 09/2020
1	Palliative Care (Palliative Therapy) 10/2019
1	Traction 01/2018
1	Lasers (Laser) 01/2018